Participation of Dr. G. Rigou at the Aquaculture Europe 2021 Conference held between 4 and 7 October 2001 in Madeira, Portugal in order to present a paper with results from subsection 2.1 of the Project entitled: “PHARMACOKINETICS AND IN VITRO EFFICACY OF FLORFENICOL IN EUROPEAN ) ”.
Conclusions
FLO is readily absorbed and rapidly eliminated from European seabass edible tissues. A PK / PD evaluation of FLO properties as a time-dependent bacteriostatic antibacterial, fits to a predictive model of Tc> MIC where Tc is the percentage of the inter-dosing interval during which the serum / plasma concentration exceeds the in vitro MIC against the target bacterium. Considering the above model. FLO could be a potentially effective ‘off label’ antibacterial against some bacterial pathogens of European seabass tested herein. A double FLO dosing, administered twice a day may aid to obtain higher circulatory daily drug levels in European seabass, but this remains to be experimentally verified.
For more information see link: https://aquaeas.org/Meeting/AE2021/
